MONOCLONAL ANTIBODY TARGETING OF FIBROBLAST GROWTH FACTOR RECEPTOR 1C AMELIORATES OBESITY AND GLUCOSE INTOLERANCE VIA CENTRAL MECHANISMS.

Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control.R1c mAb also caused weight loss Cabinet Light Fixtures in leptin-deficient ob/ob mice, leptin

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